This course examines the metabolic dysregulation that occurs in adults with obesity, insulin resistance and type 2 diabetes. Special focus is on the underlying changes in carbohydrate and fat metabolism at the whole-body and tissue level (e.g., in blood, muscle and adipose) and how lifestyle strategies (e.g., acute or chronic exercise, dietary changes) can prevent and/or treat these metabolic diseases. Research-related skills and knowledge on topics of interest will be developed through analysis of peer-reviewed literature, written assignments and/or oral presentations. Special topics may also be presented.